DOH ADMINISTRATIVE ORDER NO. 5

: Loperamide hydrochloride liquid preparation for children is banned under DOH Administrative Order No. 5, s. 1992.
: The primary reasons are that children are more sensitive to its adverse central nervous system (CNS) effects, and its safety and efficacy in children have not been established.
: The National Drug Committee and the Bureau of Food and Drugs (BFAD) recommended the ban.
: The Order became effective fifteen (15) days from its publication in a newspaper of general circulation.
: The BFAD is tasked to ensure that no loperamide hydrochloride liquid preparation for children is introduced or registered for distribution in the market.
: Yes, the ban specifically covers loperamide hydrochloride liquid preparations intended for children.
: No, such preparations shall no longer be registered or distributed in the market.
: The ban is based on recommendations from the National Drug Committee and BFAD due to safety concerns, supported by a 1990 WHO Weekly Epidemiological Record.
: The Order was signed and adopted by Juan M. Flavier, M.D., M.P.H., then Secretary of Health.
: The December 21-28, 1990 issue of the Weekly Epidemiological Record from the World Health Organization (WHO) supported the recommendation.